Endocrine Abstracts

Objective: Insulin like growth factors (IGFs) are important regulators of pancreatic β cell devolopment, growth and maintanence. Mutations in the IGF genes have been found to be associated with type 2 diabetes, myocardial infarction, birth weight and obesity. These associations could result from changes in insulin secretion. We aimed to investigate IGF- 1 gene polymorphism in obese patients with insulin resistance.Methods: We included 100 obese pati...

Introduction: IGFs (Insulin like growth factors) are important regulators of pancreatic β-cell development, growth and maintanence. Mutations in the IGF genes have been found to be associated with type 2 diabetes, myocardial infarction, birth weight and obesity. These associations could result from changes in insulin secretion. Insulin resistance plays a key role in PCOS. Based on these findings, we aimed to investigate IGF1 gene polymorphism in polycystic ovary syndrome ...